https://www.caporizzolab.org/blog daily 0.75 2025-05-19 https://www.caporizzolab.org/blog/roger-p6mbs monthly 0.5 2019-08-15 https://images.squarespace-cdn.com/content/v1/5ce82d5d7cff9a0001025c64/1565805995594-KDNI0YKWQU3ZBRC26PCY/20160125-A05A0708.jpg Blog - Roger's Story https://www.caporizzolab.org/blog/philippe-37j7s monthly 0.5 2019-08-15 https://images.squarespace-cdn.com/content/v1/5ce82d5d7cff9a0001025c64/1565804058045-462YEG020FFTE0TSYJQ5/dog-4.jpg Blog - Philippe's Story https://www.caporizzolab.org/blog/pepper-dnc73 monthly 0.5 2019-08-14 https://images.squarespace-cdn.com/content/v1/5ce82d5d7cff9a0001025c64/1565806129140-3N3COIW4L455FAXL8XFW/A05A8746-2.jpg Blog - Pepper's Story https://www.caporizzolab.org/blog/hank-p3fxr monthly 0.5 2019-08-15 https://images.squarespace-cdn.com/content/v1/5ce82d5d7cff9a0001025c64/1565805541409-VADKO8ECSUGGFH3PW6SJ/HankPortrait2.jpg Blog - Hank's Story https://www.caporizzolab.org/blog/michael-5xwp4 monthly 0.5 2019-08-15 https://images.squarespace-cdn.com/content/v1/5ce82d5d7cff9a0001025c64/1565806291853-5281R8TP875AC389ZG8W/dog-3.jpg Blog - Michael's Story https://www.caporizzolab.org/blog/tia-2emlk monthly 0.5 2019-08-15 https://images.squarespace-cdn.com/content/v1/5ce82d5d7cff9a0001025c64/1565806359829-M0YHYCNT1OB16V2YR814/dog-6.jpg Blog - Tia's Story https://www.caporizzolab.org/lab-highlights daily 0.75 2025-05-19 https://www.caporizzolab.org/lab-highlights/aha-go-red-for-women monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/58f1a78b-b144-426c-99ee-7f56c1dbc0b0/IMG_2556.jpeg Lab Highlights - AHA Go Red for Women - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/x-ray-trip-to-brookhaven-national-lab monthly 0.5 2025-05-19 https://www.caporizzolab.org/lab-highlights/bps-2025-in-san-diego monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/58af82b2-6295-4de8-afda-44acb8dd834e/IMG_2448.jpg Lab Highlights - BPS 2025 in Los Angeles, CA - Make it stand out Beach Day Trip to Santa Monica! https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1d528d01-8b7f-4539-8d65-0ac09086d118/93CE4D3B-B9AE-440F-9292-826ABE5F072B.jpg Lab Highlights - BPS 2025 in Los Angeles, CA - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/moving-into-our-new-space monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/b107fd5d-b8e3-4d1a-841c-1063b65acaf0/IMG_2768.jpg Lab Highlights - Moving into our new space! - Make it stand out Left to Right: Ronan Mullin, Melinda Wetzel, Nicole Lewis, and Jess Drozdowski! https://www.caporizzolab.org/lab-highlights/5uxbm9tc74t6td93wtzyd5xm9c73q6 monthly 0.5 2025-05-19 https://www.caporizzolab.org/lab-highlights/happy-halloween monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/c6a1f0cf-c65c-46b2-8cd7-4bfdcd5e40a0/IMG_7784+%281%29.jpg Lab Highlights - Happy Halloween - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/summer-research-crew-2024 monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/77a2e967-3d95-4984-a2ff-453cfe880e3e/LCOM_7.31.24_Caporizzo+Lab_049.jpg Lab Highlights - Summer Research Crew 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/x-ray-trip-to-brookhaven monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/780dda98-8249-4068-befd-752066c8608a/Xray+Trip.jpg Lab Highlights - X-Ray Trip to Brookhaven - Make it stand out From Left to Right: Andy Mead, Julia Shrier, Matthew Caporizzo, Brad Palmer, Raihan Kabir, Khoi Nguyen, and Greg Jacobs https://www.caporizzolab.org/lab-highlights/cvri-viridis-montis-award-winner monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/41c5892b-0ceb-407f-abf3-110dc8a89035/CVRI2.jpg Lab Highlights - CVRI Viridis Montis Award Winner - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/first-publication-out-of-the-lab monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/59e59a3a-00c1-4b4e-a4de-3b82cd8d84e6/1-s2.0-S2772976124000060-ga1_lrg.jpg Lab Highlights - First Publication Out of the Lab in JMCCPlus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/bps-2024 monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/ed0006b1-b26c-43e4-b772-7ff0af35dd3e/I_Heart_Cats.jpg Lab Highlights - BPS 2024 in Philadelphia, PA - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/aha-bike-ride monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/04dccf7b-50bc-42da-a385-648779ac6a74/IMG_2151.jpg Lab Highlights - AHA Bike Ride - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/lab-highlights/climbing-the-walls monthly 0.5 2025-05-19 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/e50cd87f-2cdb-4a65-af5b-2ff3274772cd/IMG_2514.jpg Lab Highlights - Climbing the Walls - Make it stand out Left to Right: Emmaleigh Hancock, Alexa Price, Matt Caporizzo, Brad Palmer, Henry Palmer https://www.caporizzolab.org/lab-highlights/bps-2023-in-san-diego monthly 0.5 2023-03-22 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679512733466-CJPG1F0ZORA1W34UDO4R/IMG_1842+2.JPG Lab Highlights - BPS 2023 in San Diego https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679512734276-DPEQ7BUT6HKOQ9V8E8C2/IMG_1844.JPG Lab Highlights - BPS 2023 in San Diego https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679512745398-N81V0J4ISDHQC0CBHX5O/20230220_201451.jpg Lab Highlights - BPS 2023 in San Diego https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679512735162-L4OWUXVYQB8K80P4CYY3/IMG_1875.JPG Lab Highlights - BPS 2023 in San Diego https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679512972773-S82DD1B4PGGW2JAKIWCV/20230221_152311.jpg Lab Highlights - BPS 2023 in San Diego https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679512972884-VIGP98GSSUJJM1H66HD3/20230222_180629.jpg Lab Highlights - BPS 2023 in San Diego https://www.caporizzolab.org/lab-highlights/natrevcardiol monthly 0.5 2023-03-22 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1650637058460-7EXNHZXWFC12Y0CDS24C/NatRevCardiolHeartFailure-TubulinIsoforms.PNG Lab Highlights - Paper Published in Nature Reviews Cardiology! https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1650637059239-9ELV64LU6JJ7KPZM72A9/NatRevCardiol-mechanics.PNG Lab Highlights - Paper Published in Nature Reviews Cardiology! https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1650637060077-RSSRM4L6L1D9JHNDF5I8/NatRevCardiolTOC.PNG Lab Highlights - Paper Published in Nature Reviews Cardiology! https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1650637058510-AQRVTL89AKVTIT8I28WS/NatRevCardiolHeartFailure.PNG Lab Highlights - Paper Published in Nature Reviews Cardiology! https://www.caporizzolab.org/lab-highlights/bps2022 monthly 0.5 2022-04-22 https://www.caporizzolab.org/lab-highlights/labopens monthly 0.5 2022-04-22 https://www.caporizzolab.org/about daily 0.75 2023-10-23 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/a8c50926-9b00-4e45-8dbd-378c4762ee1d/Heart_Figure_Choppage.png Our Mission - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/home daily 1.0 2025-05-19 https://www.caporizzolab.org/research daily 0.75 2022-03-08 https://www.caporizzolab.org/team daily 0.75 2025-07-10 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/0d17448b-1a7f-420f-88a0-dd4bfcfdc9c6/LCOM_7.31.24_Caporizzo+Lab_044.jpg https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/12fff77f-b8ba-4318-b447-87522e044565/CaporizzoLab_Logo_ECG_2022_Warped-svgTINYPIN.jpg Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/c3d72535-e9d4-4417-9142-3f65519055c7/ob3-DMSO11-BACKGROUND.png Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/9a7a0df4-0ced-4145-b21e-d12f8627715e/FaceShot_MSRide2018.jpg Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/c3d72535-e9d4-4417-9142-3f65519055c7/ob3-DMSO11-BACKGROUND.png Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/75bd4ccd-b0ee-467c-92de-1aeb1f3a06b3/image.png Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/465988c7-3b3f-4dcd-a950-44cda1dbe6dc/image+%281%29.png Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/4d8142b1-4745-45b9-bcdc-82cbcd3b6399/IMG_1248.jpg Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/e79665b5-6674-473a-a651-c46a963c22aa/LCOM_7.31.24_Caporizzo+Lab_083.jpg Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/97c16d26-61fa-4688-ad12-02951fcfbbb0/LCOM_7.31.24_Caporizzo+Lab_072.jpg Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/ae8be5cd-cc2b-487e-87dd-74df40d63230/LCOM_7.31.24_Caporizzo+Lab_063.jpg Team https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/bd889b0b-7da0-497e-8faf-84ed6b53bdfb/Kabir.jpg Team https://www.caporizzolab.org/services daily 0.75 2022-03-10 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg Research Projects https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg Research Projects https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg Research Projects https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/989fd813-4540-4327-9129-055855ae0f94/ob3-DMSO11-BACKGROUND.png Research Projects https://www.caporizzolab.org/donate daily 0.75 2022-03-08 https://www.caporizzolab.org/publications daily 0.75 2025-05-15 https://www.caporizzolab.org/about-the-pi daily 0.75 2022-03-14 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/6d858b77-eadf-481b-9de0-c5b0f1f6a073/MoranCaporizzo2019-14.jpg About the PI - Matthew Alexander Caporizzo, Ph.D. Dr. Caporizzo received his bachelors degree summa cum laude in Engineering Physics from the University of Pittsburgh in 2008 where he was awarded the outstanding senior award. In 2008, Matt received an Ashton Fellowship to study soft matter physics at the University of Pennsylvania under the mentorship of Dr. Russell J. Composto where Matt developed new methodology to measure the viscoelasticity of single cells using atomic force microscopy. After receiving his Ph.D. in materials science engineering at the University of Pennsylvania in 2014, Matt joined the lab of Dr. Yale E. Goldman at the Perelman School of Medicine at the University of Pennsylvania. Under the mentorship of Dr. Goldman, Matt built an interferometric scattering microscope and developed an analytical Markov model to describe the molecular motility of processive dimers which he applied to the bundle-selective motor myosin X. In 2016, Matt received an American Heart Association Post-Doctoral Fellowship to join the lab of Dr. Benjamin Prosser and study the contribution of the microtubule cytoskeleton to cardiac viscoelasticity. There Matt pioneered new approaches to interrogate the passive viscoelasticity of cardiomyocytes and myocardium and developed a computational model which demonstrates that viscous resistance of the microtubule network is sufficient to inhibit the contraction of cardiomyocytes in heart failure. In 2021, Matt was awarded an American Heart Association Career Development Award to develop engineered cardiac tissues from human samples to interrogate the mechanical feedback between the microtubule cytoskeleton and the failing cardiac extracellular matrix. In 2022 Matt was appointed as an Assistant Professor at the Larner College of Medicine at the University of Vermont where he is actively continuing his research on the molecular mechanisms that stiffen the failing heart and developing platforms to test new therapies that reverse pathological stiffening. https://www.caporizzolab.org/contactus daily 0.75 2022-03-11 https://www.caporizzolab.org/join-our-team daily 0.75 2023-03-22 https://www.caporizzolab.org/projects daily 0.75 2025-05-15 https://www.caporizzolab.org/projects/engineered-heart-tissues monthly 0.5 2023-03-22 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/99b180a6-4f14-4872-baa3-cffeb0140cdc/EHTschematic.png https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/1679516536412-BL4AXQ8E7H6NZWUMSUKN/IPScells_SPYtub_SPYact.jpg https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/34b8d21d-67c3-4387-8c80-00dbacf4995d/Screen+Shot+2023-03-22+at+3.59.34+PM.png https://www.caporizzolab.org/projects/myocardial-slice-mechanics monthly 0.5 2023-03-22 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/9f4244b4-1a4a-4583-b72f-385571b8e2fc/Screen+Shot+2023-03-22+at+4.01.12+PM.png https://www.caporizzolab.org/projects/myocytemechanics monthly 0.5 2022-03-11 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/4694ecf1-8c5a-4eb2-90c2-ef01028da4d9/ob3-DMSO11-Deconvolution-LUTS-27-Gauss-28_c1-3.png Current Projects - Molecular Regulators of Myocyte Mechanics - Make it stand out Microtubules (blue, tyrosinated; yellow, detyrosinated) and Intermediate Filaments (magenta, desmin) in the adult cardiomyocyte. https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/b9d28033-ef78-4753-b400-b3117e503200/ViscoelasticityandMTProliferation.jpg Current Projects - Molecular Regulators of Myocyte Mechanics - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.caporizzolab.org/projects/biopsymechanics monthly 0.5 2022-03-11 https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/41ca04d1-d022-42fa-ab82-b557a9eb7202/Viscoelasticity.jpg Current Projects - Cardiac Biopsy Mechanics - Make it stand out Altering myocardial viscoelastic properties changes diastolic performance. https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/e8d830b2-0150-4418-9080-374959b3284f/Caporizzo_MA_circulationaha.119.043930.fig06.jpg Current Projects - Cardiac Biopsy Mechanics Cardiac tissue from HFpEF patients is relatively more viscoelastic than HFrEF myocardium. A, Histological analysis of nonfailing versus HFrEF and HFpEF myocardium. B, Comparison of viscoelastic properties between HFrEF and HFpEF tissue. C, The relative proportion of viscoelastic to elastic stress (Stress Relaxation/Steady State Stress) as a function of strain. D, Relative energy loss (energy dissipated/energy stored) E, Effect of colchicine on stress relaxation during ascending staircase of HFrEF and HFpEF trabecula. Statistical significance determined via 2-way, repeated-measures ANOVA, *P<0.05, **P<0.01, ***P<0.001. https://images.squarespace-cdn.com/content/v1/62277b0dfd7524267e6a6046/0ac4c555-9357-4140-9785-ccba0bb37845/1824_long_snap.PNG Current Projects - Cardiac Biopsy Mechanics Picosirius Red Staining of Collagen in Human Left Ventricular Myocardium taken on Zeiss 980 with Airyscan 2 at 20x